F Methylhydrazine

Aluminium, 0048 Ammonium phosphinate, 4549 Barium phosphinate, 0210 f Benzaldehyde, 2727 1,4-Benzenediol, 2326 Bis(hydrazine)tin(II) chloride, 4064 Calcium acetylide, 0582 Calcium phosphinate, 3925 Chromium(II) chloride, 4046 Chromium(II) oxide, 4235 Chromium(II) sulfate, 4238 Copper(I) bromide, 0264 Diacetatotetraaquocobalt, 1774 Diisobutylaluminium hydride, 3076 f 1,2-Dimethylhydrazine, 0951 1,2-Diphenylhydrazine, 3511 Dipotassium phosphinate, 4425 f Ethanedial, 0719 f Formaldehyde, 0415 Formic acid, 0417 Gallium(I) oxide, 4405 Glucose, 2513 f Hydrazine, 4515 Hydroxylamine, 4493 Hydroxylaminium phosphinate, 4550 Hyponitrous acid, 4464 Iron(II) chloride, 4055 Iron(II) hydroxide, 4386 Iron(II) sulfate, 4393 Fead(II) phosphinate, 4526 Fead(II) phosphite, 4530 Fithium dithionite, 4682 Magnesium, 4685 Magnesium phosphinate, 4512 Manganese(II) phosphinate, 4514 f Methylhydrazine, 0500 Phenylhydrazine, 2366 Phosphinic acid, 4498 Phosphonic acid, 4499 Phosphonium iodide, 4510 Potassium, 4640 Potassium hypoborate, 0163... 

Triarylthiapyrylium salts react with methylhydrazine to give 3,5,7-triaryI-l-methyI-l/f-... 

Artemov and Shvaika treated a number of 2-aryl-l,3,4-oxadiazole-5(4//)-thiones (293) with methylhydrazine (R = Me) and obtained a mixture of 1-methyl-1,4-dihydro-1,2,4,5-tetrazine-6(5/f)-thiones (294) and 4-methylamino-l,2,4-triazole-3-thiones (295 R = Me) (71KGS905). A similar reaction was reported by Konig and his coworkers, who treated 5-(4-pyridyl)-l,3,4-oxadiazole-2-thione (293 Ar = py) with hydrazine (R = H) and obtained a compound which was either the l,2,4,5-tetrazine-6-thione (294 R = H) or the 4-amino-l,2,4-triazole-3-thione (295 R = H) (54CB825,56GEP953801). 

The fuel for the Aerobee rocket is a mixture of hydrazine (HjN-NH,), methylhydrazine (H3C-NH-NH2), and unsymmetrical dimethylhydrazine, ((CHj)2N-NH2). You are to follow the ligand exchange method described in Anal. Chim. Acta. 37, 102 (1967) and determine the hydrazines by the method of R.A. Penneman and L.F. Audrieth, Anal. Chem., 20, 1058 (1948). 

Methyl 2-trimethylsilyloxycyclopropanecarboxylates behave as 4-oxoalkanoate equivalents and react with hydrazine to give 4,5-dihydro-3(2/f)-pyridazinones in excellent yield, though pyridazines are not formed with phenylhydrazine <84S786>. A mixture of regioisomers is obtained when cis-aconitic anhydride is allowed to react with methylhydrazine free base in dimethoxyethane, but reaction with the sulfate in water gives the 4-carboxymethyl compound as the sole product <83H(20)2347>. 

Fi NgPjRuCijHjj, Ruthenium(ll), (Ti -cyclo-octadiene)tetrakis(methylhydrazine)-, bis hexafluorophosphate(l -), 26 74 F,204PjPdC44Hj5, PaUadium(n), bis[2-(diphenylpliosphino)ethyl)phenyl-phosphine)(l,l,l, 5,5,5-hexafluoro-2,4-pentanedionatoF, 1,1,1,5,5,5-hexa-fluoro-2,4-dioxo-3-pentanide, 27 320 F,204PdC,(,H2, Palladium, bis(l,l,l,5,5,5-hexafluoro-2,4-pentanedionato)-,... 

Hg at 20°C (68°F). Flammable. In addition to potential industrial uses, exposure to methylhydrazine can occur from ingestion of false morel mushrooms. 

Phthalic acid (101) with A-(l,2-diphenylethylidene)-A -methylhydrazine gave 2-methyl-3-(a-phenylstyryl)-l,4(27/,3/f)-phthalazinedione (102) (neat PCI3, 20°C, 8h 68%) a dozen analogs likewise. ... 

An equimolar mixture of dibenzyl ketone, methylhydrazine, and anhydrous xylene stirred 3-4 hrs. at room temp, in the presence of a trace of p-toluene-sulfonic acid, then refluxed ca. 0.5 hr. with azeotropic removal of the resulting water, an additional mole of dibenzyl ketone added, and refluxed 1 week with continued removal of the resulting water 2,5-dibenzyl-l-methyl-3,4-diphenyl-pyrrole. Y 15%. F. e., also unsym. pyrroles with 2 different ketones, s. J.-P. Chapelle et al., Bl. 1971, 280. 

A mixture of the startg. dibromoester and 3 moles methylhydrazine in ether stored 48 hrs. at room temp. -> methyl 2-methylisoindole-l-carboxylate. Y 68%. F. e. s. G. Cignarella, F. Savelli, and P. Sanna, Synthesis 1975, 252. 

Methylhydrazine added dropwise over 30 min to a soln. of startg. 2-acylene-l,3-di-thietane in acetonitrile at room temp., and the mixture refluxed for 3 h 4-ethoxycarbonyl-5-mercapto-l,3-dimethylpyrazole. Y 99%. F.e.s. N. Okajima, Y. Okada, Synthesis 1989, 398. 

Ethyl benzoylacetate (34) was reacted with methylhydrazine (35) under ultrasonic irradiation to afford l-methyl-3-phenyl-2-pyrazolin-5-one (36) (Scheme 8.12), which was obtained in excellent yields and shorter reaction times as compared with conventional condition. l-Methyl-3-phenyl-l f-pyrazol-5(4//)-one (36) was allowed to react with phenylisothiocyanate in dimethylformamide (DME) in the presence of KOH under ultrasonic irradiation at 25°C-30°C, followed by acidification with dilute hydrochloric acid (dil. HCl), which afforded the corresponding thiocarboxani-lide (37). 

Startg. chloroketone refluxed 3 hrs. with methylhydrazine in ethanol 3-p-chlorophenyl-l-methyl-4,5,6,7-tetrahydro-lH-l,2-diazepine. Y 70%. F. e. s. J.-J. Koenig and C.-G. Wermuth, Tetrah. Let. 1973, 603. 

Benzil refluxed with l-(2-aminoethyl)-l-methylhydrazine in benzene in the presence of p-toluenesulfonic acid with azeotropic water removal 6,7-dihydro-l-methyl-3,4-diphenyl-lH-l,2,5-triazepine. Y 82%. F. e. s. D. L. Trepanier, S. Wang, and C. E. Moppett, Chem. Commun. 1973, 642. 

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