F-L-Fluorodopa

Not less than 99.5% correspond to 511 keV, 1.022MeV, or Compton scatter peaks of 18F, with no individual impurity present more than 0.1% 

Since the most common method of production utilizes organomer-cury precursor, mercury is the major toxic impurity. It is determined by atomic absorption spectrometry and its USP limit is 0.5 pg/ml of L-dopa solution 

Radiochemical purity It is determined by the HPLC method or ion pair chromatography. 

Aluminum and titanium are the common impurities, determined by colorimetric methods. The USP limit of Al3+ is 10 pg/ml of the solution 

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Solid-phase electrophilic fluorination was previously used by Luthra [1] to prepare an F-L-dopa analogue, (1), for the in sim release of F-L-fluorodopa. 

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