F Fluoromethane

P F]Fluorocholine, an imaging agent used in oncology for detecting androgen-dependent and androgen-independent prostate cancers and its metastases, was prepared from bromop F]fluoromethane (Scheme 33) [143]. 

The kinetic parameters of Tc-HMPAO retention in the human brain have been studied (Lassen et al. 1988), and measurements of CBF have been compared to Xe (Andersen et al. 1988). CBF was quantified using dynamic single-photon emission computer tomography (SPECT) (Murase et al. 1992). The role of SPECT with Tc-HMPAO in ischemic stroke has been evaluated (Heiss 1983 Podreka et al. 1987). Reflow hyperemia in subacute stroke has been described as luxury perfusion (Lassen 1966) and was later explained by hyperfixation of " Tc-HMPAO (Lassen and Sperling 1993). Increased regional blood flow in subacute stroke has been measured with " Tc-HMPAO (Moretti et al. 1990). The effect of acetazolamide on CBF was reported in patients with severe internal carotid artery stenosis/occlusion (Asenbaum et al. 1995), and has been studied in primates (Dormehl et al. 1997). " Tc-HMPAO SPECT was evaluated in patients with cerebrovascular disease by comparison with F-fluoromethane positron emission tomography (PET) (Heiss et al. 1990). A pattern of focal abnormalities in CBF was derived in patients with degenerative dementia (Holman et al. 1992). 

Heiss W-D, Herholz K, Podreka I, Neubauer I, Pietrzyk U (1990) Comparison of " Tc-HM-PAO SPECT with F-fluoromethane PET in cerebrovascular disease. J Cereb Blood Flow Metab 10 687-697... 

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