Ezrin/radixin/moesin family

Members of the PSD-95 family of proteins have been shown to bind in vitro to band 4.1, an actin/spectrin-binding protein (Lue et al., 1994, 1996 Marfatia et al., 1996). Such an interaction has the potential to link NMDA receptors indirectly to F-actin, which is the predominant cytoskeleton in dendritic spines. Whether band 4.1 or other members of the ezrin-radixin-moesin (ERM) family of actin-binding proteins play a role in postsynaptic anchoring of NMDA receptors and PSD-95 is unknown. 

Bretscher, A. 1999. Regulation of cortical structure by the ezrin-radixin-moesin protein family. Curr. Opin. Cell Biol 11 109-116. 

Figure 8-17 Working model of the protein-protein interactions in focal adhesions determined by in vitro binding experiments and immunolocalization. In addition, several interactions are of relatively low affinity in solution but may be enhanced at the membrane surface. Abbreviations are ECM, extracellular matrix PM, plasma membrane p-Tyr- , unknown phosphoty-rosine-containing protein R/E/M, member of the radixin/ezrin/moesin family VASP, vasodilator-stimulated phosphopro-tein. Diagram is modified from Simon et al.285...

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