Simvastatin Ezetimibe

SimvastatirYezetimibe Simvastatin/ezetimibe 10 mg/ Simvastatin/ezetimibe Simvastatin/... [Pg.118]

Dose The recommended usual starting dose is 10 mg ezetimibe/20 mg simvastatin daily. Initiation of therapy with 10 mg ezetimibe/10 mg simvastatin daily may be considered for patients requiring less aggressive LDL-C reductions. Patients who require a larger reduction in LDL-C (more than 55%) may be started at 10 mg ezetimibe/40 mg simvastatin daily. After initiation or titration of ezetimibe/simvastatin, lipid levels may be analyzed after 2 or more weeks and dosage adjusted, if needed. [Pg.638]

Homozygous familial hypercholesterolemia The recommended dosage for patients with homozygous familial hypercholesterolemia is 10 mg ezetimibe/40 mg simvastatin daily or 10 mg ezetimibe/80 mg simvastatin daily in the evening. Use ezetimibe/simvastatin as an adjunct to other lipid-lowering treatments (eg, LDL apheresis) in these patients or if such treatments are unavailable. [Pg.638]

Renal function impairment For patients with severe renal insufficiency, do not start ezetimibe/simvastatin unless the patient has already tolerated treatment with simvastatin at a dose of 5 mg or higher. Exercise caution when ezetimibe/simvastatin is administered to these patients, and monitor them closely. Concomitant bile acid sequestrants Give ezetimibe/simvastatin either 2 hours or more before or 4 hours or more after administration of a bile acid sequestrant. Concomitant cyclosporine Exercise caution when initiating ezetimibe/simvastatin in the setting of cyclosporine. In patients taking cyclosporine, do not start ezetimibe/simvastatin unless the patient has already tolerated treatment with simvastatin at a dose of 5 mg or higher. Do not exceed 10 mg ezetimibe/10 mg simvastatin daily. [Pg.638]

Concomitant amiodarone or verapamil In patients taking amiodarone or verapamil concomitantly with ezetimibe/simvastatin, do not exceed 10 mg ezetimibe/20 mg simvastatin daily. [Pg.639]

Ezetimibe/Simvastatin (Vytorin) [Antilipemic/HMG CoA Reductose Inhibitor] Uses H rp cholest olemia Action X Absorption of cholesterol phytost ol w/ HMG-CoA reductase inhibitor Dose 10/10-10/80 mg/d PO w/ cyclosporine or danazol 10/10 mg/d max w/ amio-darone or verapamil 10/20 mg/d max -1- w/ sev e renal insuff Caution [X, -] w/ CYP3A4 inhibitors (Table VI-8), gemfibrozil, niacin >lg/d, danazol, amiodarone, verapamil Contra PRG/lactation livCT Dz, t LFTs Disp Tabs SE HA, GI upset, myalgia, myopathy (muscle pain, weakness, or tendOTiess w/ CK 10 x ULN, rhab-domyolysis), Hep, Infxn Interactions t Risk of myopathy W7 clarithromycin, erythromycin, itraconazole, ketoconazole EMS None OD Sxs unknown symptomatic and supportive... [Pg.161]

December 1998 labeling VYTORIN 10/10 (Schering) Warnings (ezetimibe/simvastatin) July 2004 labeling... [Pg.267]

Questran, Questran Light, Prevalite) Colesevelam (WelChol) Colestipol (Colestid) Ezetimibe (Zetia) Ezetimibe/Simvastatin (Vytorin)... [Pg.40]

Some combinations of lipid-altering drugs are currently available such as extended-release niacin/lovastatin and ezetimibe/simvastatin, which are more promising for lipid-lowering therapy with stronger effects and decreased adverse reactions. [Pg.114]

Flores NA. Ezetimibe + simvastatin (Merck/Schering-Plough). Curr Opin Investig Drugs 2004 Sep 5(9) 984-992. [Pg.278]

Fazio S, Guyton JR, Polis AB, Adewale AS, Tomassini JE, Ryan NW, Tershakovec A. Long-term safety and efficacy of triple combination ezetimibe/simvastatin plus extended-release niacin in patients with hyperlipidemia. Am J Cardiol 2010 105 487-94. [Pg.730]

Averna M, ZaninelK A, Le Grazie C, Gensini GF. Ezetimibe/simvastatin 10/20mg versus simvastatin 40mg in coronary heart disease patients. J Clin Lipidol 2010 4 272-8. [Pg.680]

Fabrizio M, Alessandra Q, Francois M. Ezetimibe/simvastatin. Expert Opin Drug Saf 2009 8 715-25. [Pg.680]

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