Extraction solvent selection, criteria

Both of these MIP preparation procedures have their advantages and limitations [20, 21]. For instance, the size of the analyte molecule is not a discriminating criterion in covalent imprinting since the template selectively determines the interaction sites. In contrast, non-covalent imprinting has the advantage of being simpler since an additional synthetic step is not required to introduce the template into the polymer matrix. Moreover, removal of the template via extraction with the suitable solvent solution is simple and mostly complete for the non-covalent imprinting. 

To develop a new liquid-liquid extraction process in the nuclear held, it is therefore imperative to consider the stability of the molecules proposed as a major criterion and to integrate systematic degradation studies in order to check the robustness of the solvent submitted to radiolysis, particularly in terms of efficiency and of selectivity. 

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