Expression of aberrantly rearranged loci

Transcripts are often detected from the excluded allele, although both the rate of transcription and the level of mRNA accumulation varies from cell line to cell line, depending upon the nature of the aberrant rearrangement (see [28] and references therein). In several cell lines, aberrantly rearranged alleles have been found to be translated into an immunoglobulin polypeptide fragment that is degraded within the cell and does not contribute to the expressed antibody [29,30], 

In the case of several D-JH integrations, transcripts have been detected that initiate a few nucleotides upstream of the rearranged D segment [31,32], Some of these DJh-Cm transcripts have been shown to be translated into polypeptides that are presumed to be synthesized on membrane-bound polysomes as the nucleotide sequences suggest the presence of a hydrophobic leader at the amino-terminal end of the polypeptide [31] and, at least in one cell line, the protein has been shown to be glycosylated [32], 

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