Expression and recording systems

2 Expression and recording systems HEK-293 cells have been transfected with cDNA for hERG-1 to produce a stable expression system (the cell line was developed in the lab of Dr. Craig January at the University of Wisconsin). 

The relevance and relative importance of these measurements in conjunction with all of the other components of cardiovascular safety assessment is still not clear. Certainly it is influential in making drug development decisions [21] but should not be a critical determining factor on its own. 

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