Experimental signatures of tunneling

OBSERVATIONS THAT DO NOT DEFINITIVELY INDICATE TUNNELING Large isotope effects per se do not indicate tunneling 

There are ways in which temperature-independent isotope effects can arise in the absence of tunneling. 

The valid criteria for establishing tunneling in hydrogen-transfer processes that have been encountered in the consideration of various examples above are  

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Hydride-transfer reactions involving other cofactors 64 Hydrogen-atom transfer reactions 67 Proton-transfer reactions 69 Experimental signatures of tunneling 70... 

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