Experiment 3.7 Determination of the Formation Constant for Pyridine

EXPERIMENT 3.7 DETERMINATION OF THE FORMATION CONSTANT FOR PYRIDINE BINDING TO A/,A/ -DISALICYLALDEHYDE-1,3-PROPANEDI IMINENICKEL(II), [Ni(salpd)], USING THE DOUBLE RECIPROCAL (BENESI-HILDEBRAND) METHOD 

The formation of metal complexes can be viewed as a series of equilibria, equations (3.16)—(3.18), characterized by successive formation or equilibrium constants, Kn. 

Alternatively, the overall stability constants, /3 , can be expressed, equations (3.19)— (3.21). 

The successive equilibrium constants are related to the overall stability constants by /3 = KiK2K3,. .., Kn. 

Both steric and electronic effects contribute to the magnitude of the formation constant. The effect of sterics are often assessed with the use of molecular mechanics calculations (Chapter 6) and electronic effects, by studying linear free energy relationships— the relationship between free energies and rates of complex formation. HSAB and CFT (or LFT) are used regularly to predict and rationalize metal complex stability. 

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