Exogenously Applied Drugs Mimic Drug Usage

Can Exogenously Applied Drugs Mimic Drug Usage  

Analogous experiments were performed with PCP. In these experiments, hair from a PCP drug user was exposed to a solution of p-methylPCP at a concentration of 1 pg/mL for 1 h. The final extract contained 2.3 ng of PCP/mg of hair, whereas p-methylPCP was found at a concentration of 12 ng/mg of hair. More of the drug surrogate was found in the hair than the PCP incorporated in vivo. Neither the extraction kinetics nor the ratio of PCP in hair to that of the last phosphate wash clearly distinguished this hair specimen as contaminated by p-methylPCP. 

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D. Can Exogenously Applied Drugs Mimic Drug Usage ... 

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