Exercise testing safety during

The safety of G-CSF stimulation in patients with CAD has been questioned in two recent studies. Hill et al. [138] report the results of administration of 10 mcg/kg/day of G-CSF for 5 days in patients with chronic CAD n = 16). There was no clinical benefit as assessed by exercise stress testing and dobuta-mine cardiac MRI. Additionally two patients in the G-CSF group developed serious adverse events related to the therapy (one non-ST elevation MI one MI causing death). Zbinden et al. [139] also tested the efficacy of the same G-CSF dose in patients with chronic CAD ( = 7). The invasive endpoint collateral flow index was significantly better in the G-CSF treated patients when compared to the placebo group. However, two patients in the G-CSF treated group developed acute coronary syndrome during treatment. 

While the laboratory exercises listed in this book s appendix have been exhaustively tested for safety and all attempts have been made to use the least hazardous chemicals and procedures possible, the authors and publisher cannot be held liable for any injury or damage which may occur during the performance of these exercises. ... 

The safety and protection of employees, company assets, and the community in which the company resides is incumbent npon the corporation. Hopefully, an emergency response plan will need to be used only during testing and exercises. However, should an incident occur, a good plan will save time, resources, money, and more importantly, lives. It will also preserve community confidence in the company, which is a very important aspect of successful business. 

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