Lisinopril Exenatide

Drugs that may be affected by exenatide include acetaminophen, digoxin, lisinopril, lovastatin, oral antibiotics, and oral contraceptives. 

A brief report states that spirapril does not have a pharmacokinetic interaction with glibenclamide. The manufacturer of exenatide notes that, in a study in hypertensive patients exenatide 10 micrograms twice daily did not alter the steady-state AUC or maximum level of lisinopril 5 to 20 mg daily, but it did delay the time to maximum level by 2 hours. However, exenatide did not alter the blood-pressure lowering effect of lisino-pril. ... 

Subcutaneous exenatide has no important pharmacokinetic interaction with lisinopril, and would therefore not be expected to have a pharmacokinetic interaction with any other ACE inhibitor, although this needs confirmation. 

This study demonstrates that exenatide slows gastric emptying, and has the potential to delay the absorption of other drugs. The manufacturer recommends that exenatide should be used with caution in patients receiving oral drugs that require rapid gastrointestinal absorption. They do not give any specific examples. However, they do note that exenatide does not affect the absorption of lisinopril. 

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