Exenatide Acetaminophen

Drugs that may be affected by exenatide include acetaminophen, digoxin, lisinopril, lovastatin, oral antibiotics, and oral contraceptives. 

Blase E, Taylor K, Gao H, Wintle M, Fineman M. Pharmacokinetics of an oral drug (acetaminophen) administered at various times in relation to subcutaneous injection of exenatide (exendin-4) in healthy subjects. J Clin Pharmacol 2005 45 570-7. 

The rate and extent of paracetamol (acetaminophen) absorption are reduced by exenatide, even when the paracetamol is given up to four hours after the exenatide. The manufacturer therefore recommends that exenatide be used with caution with drugs that require rapid gastrointestinal absorption or drugs that require a threshold level for efficacy (such as the oral contraceptives and some antibacterials). Further study is necessary to establish the clinical relevance of any of these potential interactions. 

In a study using paracetamol (acetaminophen) as a marker of gastric emptying, subcutaneous exenatide 10 micrograms delayed and reduced the maximum plasma levels of paracetamol from 0.6 to 4.2 hours and by 37% to 56%, respectively. The overall extent of absorption was slightly reduced (14% to 24% reduction in AUC). This effect was seen when paracetamol was given simultaneously with exenatide, or one, two, and... 

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See also in sourсe #XX -- [ ]

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