Exclusionary Criteria

Alteplase initiated within 3 hours of symptom onset has been shown to reduce the ultimate disability due to ischemic stroke. A head CT scan must be obtained to rule out hemorrhage before beginning therapy. The patient must also meet specific inclusion criteria and no exclusionary criteria (Table 13-2). The dose is 0.9 mg/kg (maximum 90 mg) infused IV over 1 hour after a bolus of 10% of the total dose given over 1 minute. Anticoagulant and... 

Preliminary evidence that this issue is an important one for clinicians derives from post hoc analyses of the double-blind, placebo-controlled paroxetine withdrawal study (Geller et ah, 2001b), in which no strict exclusionary criteria were applied. In that study, 193/ 335 (58%) patients had at least one psychiatric disorder in addition to OCD and 102/335 (30%) had multiple ( 2) other disorders. The response rates in patients with comorbid ADHD, tic disorder, or oppositional defiant disorder (56%, 53%, and 39%, respectively) were significantly less than in patients with OCD only (75%, [ITT LOCF] p < 0.05). Psychiatric comorbidity was also associated with a greater... 

Portal vein thrombosis without cavernous transformation and hepatopetal flow is a well known and accepted relative contraindication for other types of transarterial therapy (e.g. TACE). However, there is controversy as to whether the same exclusionary criteria should be applied for the selection of patients for microsphere treatment. The size of the spheres... 

Exclusionary - criteria that, if not satisfied or exceeded, will categorically exclude all or part of a site from further consideration or,... 

With regard to the exclusionary criteria, nominated sites can be excluded from further consideration if the criteria are breached. Decisions on exclusion as a result of these criteria will not be influenced by plant design considerations. The exclusionary criteria identified in the SSA are ... 

The mirtazapine studies did not screen for hepatitis C as an exclusionary criterion for study enrollment, so these elevations may have been due to the periodic exacerbations of this chronic infection rather than being caused by the drug. 

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