Example Application of the Transform-Both-Sides Approach to a Pharmacodynamic Model

EXAMPLE APPLICATION OF THE TRANSFORM-BOTH-SIDES APPROACH TO A PHARMACODYNAMIC MODEL 

XomaZyme-791 (XZ-791) is a monoclonal antibody coupled to an immunotoxin, Ricin toxin A, devel- 

To account for the skewness, the transform-both-sides methodology was used with a Box-Cox transformation. The geometric mean to the data was —27.1%. The SAS code to do the analysis is shown in Chapter Appendix 2. Emax was estimated at —43.1 6.3%, whereas D50 was estimated at 11.3 2.9 mg. X was estimated at — 1.39. The resulting goodness of fit plot is shown in Fig. 4.14. The fit appeared to be very similar to the untransformed Emax model, but this time the p-value testing the 

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