Evolutionary design circle

Only a small number of compounds is chosen for synthesis in the first step at random. The compounds are then tested in a biochemical or biological assay, and the design algorithm selects a new set of compounds from the virtual Hbrary automatically [131, 132]. 

Obviously, this method requires a very close co-operation between design, synthesis, and biochemistry groups to achieve a rapid run through the circle. However, several examples are published which demonstrate the power of this strategy (e.g., only 300 compounds from a 64000000-hexapeptide Hbrary were synthesized in ref [131]). 

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Optimization based on activities (evolutionary design circle). 

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