Evolutionary design

The design and testing of these developmental plants are well underway. The evolutionary designs have received final design approval from the U.S. NRC. As of 1995 evolutionary ALWR designs very similar to these, by the same U.S. manufacturers, are already being built in Asia the GE-Advanced BWR in Japan and the ABB-CE System 80+ PWR in South Korea. The N-4 PWR is under constmction in Prance, and the SizeweU PWR has completed constmction and has initiated operation in the U.K. 

Bentley PJ 1996 Generic Evolutionary Design of Solid Objects using a Genetic Algorithm. PhD thesis, Division of Computing and Control Systems, School of Engineering, The University of Huddersfield. 

Miller JF, Job D and Vassilev VK 2000 Principles in the evolutionary design of digital circuits - part I. Genetic Programming and Evolvable Machines 1(1-2), 7-35. 

Information on various parameters is required in order to make evolutionary design of biomolecules efficient. There are, for example, population sizes, amplification factors, mutation rates, reaction volumes, and many other factors that strongly influence the outcome and the efficiency of an evolution experiment. The individual parameters are not independent and therefore simple estimates based on uncorrelated superposition are likely to be incorrect. The model introduced earlier in this chapter allows to implement computer simulations that are suitable to clarify the role of individual parameters and to provide estimates on the optimal choices. 

Fig. 5. Selection cycles in evolutionary design of biopolymers. The optimization of the desired molecular properties and functions is achieved iteratively in consecutive selection cycles. Each cycle consists of the following three phases amplification, diversification, and selection.

RATIONAL EVOLUTIONARY DESIGN THE THEORY OF In Vitro PROTEIN EVOLUTION... 

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