Eukaryotic transmembrane signaling processes

Signal hypothesis for the transmembrane transfer of secreted or membrane proteins, appears as a rather general process occurring in prokaryotes as well as in eukaryotes. Furthermore it does not seem specific for proteins synthesized by RER-bound polysomes and has also been described for proteins synthesized by free polysomes especially peroxisomal (Goldman and Blobel, 1978) and mitochondrial proteins (Maccechini et aU 1979, Cote et a/., 1979). 

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