Ethylidene bisphosphonates

A-derivatives of (2-amino-1-ethylidene)bisphosphonic acid. The addition reactions... 

Synonyms Ethane-1-hydroxy-1,1-diphosphonic add, tetrasodium salt (1-Hydroxy-ethylidene) bisphosphonic add, tetrasodium salt (1-Hydroxyethylidene) diphos-phonic acid, tetrasodium salt 1-Hydroxyethylidene-1.1 -diphosphonic acid, tetrasodium salt Na4HEDP Phosphonic acid. (1-hydroxyethylidene) bis-, tetraso-dium salt Tetrasodium 1-hydroxyethane-1.1-diphosphonate Tetrasodium (1-hydroxyethylidene) bisphosphonate Tetrasodium 1-hydroxyethylidene-1.1-diphosphonate... 

Cohen H, Alferiev IS, Monkkonen J, et al. Synthesis and preclinical pharmacology of 2-(2-aminopjTimidinio) ethylidene-l,l-bisphosphonic acid betaine (ISA-13-l)-a novel bisphosphonate. Pharm Res 1999 16 1399-1406. 

---