Ethyleneammonium diacetate

This three-component reaction as the key step of this synthesis is called a domino-Knoevenagel-hetero-Diels-Alder reaction. Domino reactions are defined as processes of two or more bond forming reactions in which a subsequent transformation takes place by virtue of the functionalities introduced in a former transformation.2,16 The tetrahydrocarbolinaldehyde 11 first reacts in a Knoevenagel type condensation with Meldrum s acid 14 and ethyleneammonium diacetate 41 as the catalyst to oxabutadiene 44 which then undergoes a Diels-Alder reaction with enol ether 13. 

Catalytic amounts of the neutral ammonium salt ethyleneammonium diacetate 41 are suitable to deprotonate C,H-acidic Meldrum s acid 14. The resulting carbanion 42 undergoes nucleophilic attack to the... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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