Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Ethyl thiophene-3-carboxylate, metallation

Thienylzincates are available using lithium di-zW-butyltetramethylpiperidinozincate (TMP-zincate) <1999JA3539> thus, ethyl thiophene-3-carboxylate is easily metallated at C(2) at room temperature, subsequent reaction with iodine giving ethyl 2-iodothiophene-3-carboxylate in 89% yield. Similarly ethyl thiophene-2-carboxylate gives the 5-iodo derivative in 62% yield. [Pg.463]

See other pages where Ethyl thiophene-3-carboxylate, metallation is mentioned: [Pg.759]    [Pg.760]    [Pg.113]    [Pg.112]    [Pg.302]    [Pg.466]    [Pg.89]    [Pg.561]    [Pg.88]    [Pg.295]    [Pg.324]    [Pg.123]    [Pg.391]    [Pg.88]   
See also in sourсe #XX -- [ Pg.463 ]



SEARCH



Carboxylic metalation

Ethyl 4 -carboxylates

Metal carboxylates

Metalation thiophenes

Thiophene-4-carboxylate

Thiophenes metallation

© 2024 chempedia.info