2- oxo-cyclohexanecarboxylate, ethyl

Keywords ethyl 2-oxo-cyclohexanecarboxylate, ethyl acrylate, Michael addition, trifluoromethanesulfonic acid... 

The arylation reaction of 1,3-dicarbonyl compounds was extended to the use of variously substituted triarylbismuth carbonates. The electronic properties of the substituents of the arylbismuth do not influence significantly the overall yield of arylated products. Arylation of ethyl 2-oxo-cyclohexanecarboxylate (34) with substituted triarylbismuth carbonate derivatives afforded the products in yields ranging from 81 to 90%. 

Chinchona alkaloids, such as quinine, are readily available quinuclidine chiral bases which have been used extensively in catalytic Michael additions239 243. Methy 1-2,3-dihydro-1-oxo-l/f-in-dene-2-carboxylate (1) is most frequently used as the Michael donor in these studies. Enantiose-lectivities as high as 76% are reached in the additions to 3-buten-2-one. Modest enantioselec-tivities (< 67%) were also obtained with ethyl 2-oxo-l-cyclohexanecarboxylate and methyl l,3-dihydto-3-oxo-l-isobcnzol urancarboxylate244 245. 

Ethyl 2-oxocyclohexanecarboxylate Cyclohexanecarboxylic acid, 2-oxo-, ethyl ester (8,9) (1655-07-8)... 

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