Ethyl methylmalonyl chloride

An improvement in this synthesis results from the use of the thallium salt of f-butyl acetoacetate in place of ethyl acetoacetate, and ethyl methylmalonyl chloride may replace the diacyl dihalide (75S259). 

Nitriles condense with malonyl chloride to give 2-chloro4,6-dihydroxypyii-dines (MI-174) in 23 to 63% yield and/or the pyrimidones (XII-17S) or chloropyranooxazines (Section I.5.C.) depending on conditions. 5-Bromo-3-carbethoxy-2-chloro-4,6-dihydroxypyridine (XII-176, R = CO2C2H5) is prepared either by bromination of MI-174 (R = C02Et) or by cyclization of bromomalonyl chloride and ethyl cyanoacetate. Methylmalonyl chloride did not react with propionitrile. The product from acetonitrile and malonyl chloride, first described as 2-chloro-4,6-dihydroxypyridine (MI-174,R = H), is6-chloro-2-methyl-4-pyrimidone (XI-175, R = H). ... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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