Ethyl 5-hydroxyhept-6-enoate, synthesis

Fischer and Pietruszka have reported the efficient synthesis of both enantiomers of ethyl 5-hydroxyhept-6-enoate (3, Scheme 4.3) using isolated alcohol dehydrogenases (ADHs) and 2-propanol as cofactor recycling system in a coupled-substrate approach [33]. 6-Hydroxy esters have been used as key intermediates for a variety... 

Scheme4.3 Synthesis of enantiopure ethyl 5-hydroxyhept-6-enoate (3) employing isolated ADHs.

Fischer, T. and Pietruszka, J. (2007) Efficient synthesis of either enantiomer of ethyl 5-hydroxyhept-6-enoate. Adv. Synth. Catal., 349 (8-9), 1533-1536. 

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