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4-Ethyl-4-hydroxy-2-methyloctanoic acid

N-Boc leucine was converted to an acid chloride by treatment with isobutyl chloroformate. Subsequent treatment with diazomethane gave the diazoketone (6.241), which was treated with silver benzoate. This led to a Wolff rearrange-mentl40 and formation of 6.242. I ll Reduction of the ester moiety to an aldehyde with diisobutylaluminum hydride allowed condensation with the lithium enolate of ethyl acetate to give 6.243. Saponification led to N-Boc-5-amino-3-hydroxy-7-methyloctanoic acid (6.244, given the pseudonym AHM0A).1 H Amino acid... [Pg.227]

See other pages where 4-Ethyl-4-hydroxy-2-methyloctanoic acid is mentioned: [Pg.21]    [Pg.22]    [Pg.80]    [Pg.97]    [Pg.40]    [Pg.42]    [Pg.43]    [Pg.21]    [Pg.22]    [Pg.80]    [Pg.97]    [Pg.40]    [Pg.42]    [Pg.43]    [Pg.8]   


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3- Ethyl-5-hydroxy

4 Ethyl 4-hydroxy 2 methyloctanoic

4-Ethyl-4-hydroxy-2-methyloctanoic acid 7-lactone

Hydroxy ethylation

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