Ethyl fluorene-9-carboxylate

Addition of Carbenes. Addition of dichlorocarbene to either 1--methoxy- or 1,2-dimethoxy-biphenylene takes place in the ring bearing the substituents, occurring only at the bonds which the accepted formula of biphenylene implies as having the highest double bond character [168,172,173], These results have been taken to provide evidence of partial bond fixation in the biphenylene molecule [172,173] Earlier work had shown that the product of addition of ethoxy-carbonylcarbene to biphenylene was ethyl fluorene-2-carboxylate and its formation was rationalised in terms of an initial addition of the carbene to the 2,3-bond of biphenylene, followed by a series of rearrangements [125,174]. 

Charge transfer complexes also form from poly(vinyl carbazole) that acts as the donor, with poly [2-(methacroyloxy)ethyl-4,5,7-trinitro-9-oxo-2-fluorene-carboxylate] that acts as the acceptor [250] ... 

Dow Chemicals group and coworkers [276,350] synthesized similar triarylamine-fluorene copolymers 251 and 252, possessing carboxylic acid substituents, via hydrolysis of the corresponding ethyl ester polymers, prepared by Suzuki polymerization. Due to the very polar substituents, the copolymers 251 and 252 are only soluble in polar solvents such as DMF but not in aromatic hydrocarbons as toluene or xylene, which allowed simple fabrication of multilayer PLEDs by solution processes (Chart 2.65). 

Methylfluorene has been prepared by cleavage of ethyl 9-methyl-9-fluorenylglyoxylate,4 by the decarboxylation of 9-methylfluorene-9-carboxylic acid,4 by the decarboxylation of 9-fluorenylacetic acid,6 by the cleavage of 9-methyl-9-acetyl-fluorene with alcoholic potassium hydroxide or soda-lime,6 by the reduction of 9-methyl-9-fluorenol with hydriodic acid in acetic acid,7 by the reaction of 9-fluorenyllithium 8 or -sodium 9 with methyl iodide or methyl sulfate,9 by the cyclization of diphenylmethyl carbinol over platinum-on-carbon at 300°,10 by the reaction of ethyl 9-methoxymcthyl-9-fluorcnylcarboxylate,11 by the diazotization and heating of 2-ethyl-2-aminobiphenyl,12 by the dehydration and then reduction of 9-mcthyl-9-fluorcnol,13... 

To a solution of the S-(+)-4-acethoxy-9-[2-(5-ethyl-l,2,3,6-tetrahydro-pyridin-3yl)-l-(lH-indol-2-yl)-l-methoxycarbonyl-ethyl]-3a-ethyl-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,ll,12,12b-octahydro-lH-6,12a-diaza-indeno[7,l-ca]fluorene-5-carboxylic acid methyl ester in dioxane and glacial acetic acid was added 37% aqueous formaldehyde and the mixture stirred at 35°C for 24 h. The solution was evaporated in vacuo and the residue suspended in chloroform and washed with cold aqueous 5% K2C03 solution. The chloroform layer was dried (MgS04), filtered, and evaporated. The residue was chromatographed eluting with EtOAc/MeOH, 10% NH4OH to give the product navelbine. 

Hydroxy-[ 1,1 -binaphthalene]-2-carboxylic acid, see H-00131 Di-2-pyridinylethanedione bis(2-quinolinylhydrazone), D-01067 l,12-Di-2-thienyl-2,5,8,ll-tetrathiadodecane, D-01115 1 -(9//-Fluoren-9-yl)ethyl carbonochloridate (+ )-form, in F-00017... 

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