Ethyl dimethylaminopropyl-carbodiimide

DCC= 1,3-dicyclohexylcarbodiimide, DIC = 1,3-diisopropyl-carbodiimide, EDC = 1 -ethyl-3-(3-dimethylaminopropyl)carbodiimide. 

AT-Acyl-L-HSL can be conveniently prepared in excellent yields by the acylation of l-HSL either with the corresponding carboxylic acids activated with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) in a water/ 1,4-dioxane (1 1) solvent system or with the corresponding acid chlorides in dichloromethane (DCM) in the presence of triethylamine (Scheme 4) [15,16, 37,53]. 

Carbodiimide Coupling of Peptides to Carrier Proteins with 1 -Ethyl-3-(3-Dimethylaminopropyl)-Carbodiimide (EDAC, EDO... 

EDC 1 -Ethyl-3-(3-dimethylaminopropyl)carbodiimide HMDS Hexamethyldisilazane HOBT 1-Hydroxybenzotriazole MS-4 A Molecular sieves 4 A... 

Table II. Content of Some Amino Acids (Gram/16 Grams Nitrogen) of Soy Protein Modified by Covalent Binding of Methionine and Tryptophan Using the Water-Soluble 1 -Ethyl-3- (3-dimethylaminopropyl) carbodiimide (24)...

The Ox group can be removed by reduction, either by palladium-catalyzed hydrogenation (quantitative) or by use of sodium in liquid ammonia (75-85 % yield). The Ox group can also be cleaved by oxidation with excess m-chloroperbenzoic acid followed by hydrolytic workup (70%). Simple Ox dipeptides have been prepared using 1-ethyl-3-(3 -dimethylaminopropyl)carbodiimide hydrochloride (1, 371). The free dipeptides... 

The O-benzylated aldehyde 517 was also coiu erted into the a,p-unsaturated ester 522 through Wadsworth-Emmons reactioiT-- with ethyl 2-(diethoxyphosphono)acetate5 ° in excellent yield (Scheme 88). The intermediate alkene 522 was subjected to Sharpless asymmetric dihydroxylalion " to afford the diol ester 523 in excellent yield and with a diastereoselectivity in excess of 95 5. Subsequent to alkali-catalyzed hydrolysis of 523, the carboxylic acid obtained was condensed with the p-lolucncsulfonalc salt of glycine benzyl ester or phenylalanine benzyl ester, by the action of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC), to afford the benzyl-protected amide derivatives catalytic... 

Novel cyclic di- and triphosphate derivatives of 3 -amino-3 -deoxyadenosine-5 -diphosphate (75) and triphosphate (76) have been prepared " by cyclisation of the respective 5 -di- and triphosphate derivatives of 3 -A -Boc-3 -amino-3 -deoxyadenosine using the water-soluble carbodiimide 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC), followed by removal of the Boc protecting group with TFA. The acyclic polyphosphate precursors were prepared according to Yoshikawa and Ludwig after first dissolving the nucleoside in hot triethylphosphate. The reaction proceeds via the intermediacy of the 5 -phosphorodichloridate derivative, partial hydrolysis of which gives the monophosphate, whilst traces of pyrophosphoryl chloride result in... 

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