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Ethyl -4-chloro-3-hydroxybutyrate

Ethyl 4-chloro-3-hydroxybutyrate (EHCB) is an important intermediate in the production of l-camitine and the cholesterol-lowering Pfizer drug Lipitor (see Chapter 31). The ruthenium catalyst, [Ru(p-cymene)I((S)-TMBTP)]+E, has been reported to reduce ethyl 3-chlorobutyrate in 97% ee with S/C ratios of 20,000 (Scheme 12.48).87,157 This chemistry has been reported at scales >100 kg.87... [Pg.219]

Jeon SJ, Hong WH. Separation of ethyl (R) 4-chloro-3-hydroxybutyrate from racemic mixture by using bulk liquid membrane. In Proceedings of the 4th International Conference on Separation Science and Technology, Nanning, China, February 18-21, 2004 561-564. [Pg.270]

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See also in sourсe #XX -- [ Pg.106 ]



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