Ethyl 2-bromopropanoate

The synthesis of ethyl 2-bromopropanoate (Expt 5.150) illustrates the preparation of an acyl chloride and its ready bromination in the a-position in the presence of red phosphorus. The resulting bromoacyl chloride is converted into the a-bromoester on reaction with an alcohol. 

Ethyl 2-bromopropionate (ethyl 2-bromopropanoate) ethyl 3-bromopropionate (ethyl 3-bromopropanoate)... 

RuCl2(=CHPh)(P(cC5H9)3)2 fcpp = 23.15 x 10 s ) was somewhat more active than the PCy3 analogue (/Capp = 21.05 x 10 s ) for the polymerisation of methyl methacrylate. Effective initiators were ethyl 2 bromo-2-methylpropanoate, ethyl 2-bromopropanoate, (1-bromoethyl)benzene and (l-chloroethyl)benzene, whereas tetrachloromethane proved to be... 

With Trimethylchlorosilane. Rather recently [60] it was found that activation of zinc with TMClSi augmented the yield of Zn-Barbier reactions with allylic halides considerably. This unexpected activation by the silane was found earlier for Reformatsky reactions with ethyl 2-bromopropanoate [61] also trimethylchlorosilane-activated lead was applied in Pb-Barbier reactions with crotyl bromide [62] and allyl bromide [63]. 

The most fundamental reaction involves displacement of a halide by cyanide ( NC ), as in the reaction of ethyl 2-bromopropanoate and sodium cyanide to give... 

Ethyl 2-bromopropanoate Ethyl 3-bromopropanoate 2-Ethylbutanal Ethyl butanoate 2-Ethylbutanoicacid... 

Explain why the reaction of ethyl 2-bromopropanoate with zinc and acetophenone gives a pair of isomers. 

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