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2- Ethoxycarbonyl-3-methylthiophene

Substituted 3-hydroxythiophenes are convenient starting-points for the synthesis of the thieno[3,2-Mthiophene system. Shvedov et obtained 50% of 3-chloro-3-ethoxycarbonyl-5-methylthiophene-2-aldehyde (110) from 3-ethoxycarbonyl-4-hydroxy-2-methylthiophene (109) by Vilsmeier formylation at 100°. Reaction with thioglycolic ter formed 3-ethoxycarbonyl-5-methoxycarbonyl-2-methylthieno[3,2-6]-thiophene (111) [. (36)]. [Pg.148]

A -acyl-a-amino-acid (108). 2-Bromo-3-methylthiophen has been carboxylated in the 5-position in high yield, using pyrocatechol dichloromethylene acetal. After esterification, the bromine was reduced by zinc dust, providing a route to isomer-free 4-bromothiophen-2-carboxylic acid. In the presence of stannic chloride, thiophen reacts with ethoxycarbonyl isocyanate or isothiocyanate to give iV-ethoxycarbonylthiophen-2-carboxamide and JV-ethoxycarbonylthiophen-2-thiocarboxamide, respectively. ... [Pg.258]

See other pages where 2- Ethoxycarbonyl-3-methylthiophene is mentioned: [Pg.887]    [Pg.920]    [Pg.197]    [Pg.887]    [Pg.920]    [Pg.197]    [Pg.426]   
See also in sourсe #XX -- [ Pg.82 , Pg.231 ]

See also in sourсe #XX -- [ Pg.82 , Pg.231 ]

See also in sourсe #XX -- [ Pg.82 , Pg.231 ]

See also in sourсe #XX -- [ Pg.82 , Pg.231 ]



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2-Methylthiophene

4 -ethoxycarbonyl

Ethoxycarbonylation

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