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Formaldehyde acetals are effectively labilized by Lewis acids like ZnBr or TiCU if a second oxygen atom in a p-position promotes the coordination of the metal. This is used in the removal of the 2-meth-oxyethoxymethyl (MEM) ethers (33 Scheme 25). They were designed to protect alcohols with formation and cleavage under aprotic conditions and were advantageously used in syntheses of brefeldin A (34) and gibberelic acid. A variant of this type of protecting group is the 2-methoxyphenoxymethyl moiety. ... [Pg.648]

See other pages where Ethers, 2-methoxyphenoxymethyl is mentioned: [Pg.119] [Pg.119] [Pg.648]