Ethers—cont structure

Fig. 11 Three-dimensional structures of epothilones determined in different environments (O red, S yellow, N dark blue). Top structures of free EpoA determined by X-ray crystallography from dichloromethane/petroleum ether (top left [9 8] (a)) and from methanol/water (top right [143](b)). Bottom structures of EpoA bound to tubulin determined by solution NMR in aqueous medium (bottom left [96]) and by electron crystallography from zinc-stabilized tubulin sheets (bottom right [26]).(a) The crystal structure data have been available from the author to interested research groups since October 1995.(b) H.-J. Hecht, G. Hofle, unpublished results CCDC 241333 and CCDC 241334 contain the crystallographic data of this structure. These data can be obtained free of charge via www.ccdc.cam.ac.uk/conts/retiieving.html (or from the Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB2 1EZ, UK fax (+ 44) 1223-336-033 or deposit cede. cam. ac. uk)...

FIGURE 18.16 (cont d). Inclusion of lutidine by a diol. Powder diffraction photographs of (e) the host-guest complex, (f) the host structure after guest molecules have been desorbed (dried at 120° for 24 hours), and (g) the host structure grown from diethyl ether before guest has been introduced. Courtesy L. Nassimbeni. 

Table 3.3 Chemical Structures of Fluorinated Diamines with Flexible Ether Linkages—cont d...

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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