Propanolamines ethanolamines

Alkanolamines Aminoethylethanolamine Diethanolamine Diethylethanolamine Dimethylethanolamine Ethanolamine Propanolamine Triethanolamine... 

So far we have seen the reactions of chlorocyclophosphazenes with reagents that may be termed monofunctional. For example, a phenol in its reactions with chlorocyclophosphazenes will react as a nucleophile and form N3P3(OPh)6 containing P-0 linkages. If instead of a phenol we used a biphenol we will have two sites that can react with the phosphorus centers. In this manner there are several difunctional reagents such as diamines (ethylenediamine, 1,3-diaminopropane, phenylenediamine), diols (ethyleneglycol, 1,3-propanediol, catechol), and amino alcohols (ethanolamine, propanolamine, o-aminophenol) [2,15]. 

Tan, S. L., Kopczynski, M. G., Bachovchin, W. W., Orme-Johnson, W. H., and Babior, B. M., 1986, Electron spin-echo studies of the composition of the paramagnetic intermediate formed during the deamination of propanolamine by ethanolamine ammonia-lyase, and AdoCbl-dependent enzyme, J. Biol. Chem. 261 348303485. 

Compounds 33-36 were designed for examination of the conformational effects of both the ethanolamine and the propanolamine series of local anesthetics within the same conformationally rigid ring framework. Both 33 and 36 were considered conformational analogs of procaine in which the N-C-C-0... 

A irons configuration appears to be more beneficial in ethanolamine-type local anesthetics binding to biological receptors while a gauche cis) configuration appears to be more beneficial for propanolamines. Thus the local anesthetic activity was in the order 33>34>35>36>procaine. The duration of action of 33 was three times that of procaine in the intra-dermal wheal assay in guinea pigs [34]. 

Aminoalcohols such as 2-aminoethanol(ethanolamine, Heta) and 2-amino-1-pro-panol(propanolamine, Hpra) have been known to combine as a neutral bidentate or as a deprotonated aminoalcoholate In 1973, Ogino et al. communicated CD spectral studies of [Co(en)2(Heta)p and [Co(en)2(L-Hpra)fthe complexes were prepared from frans-[Co8r2(en)2] and the Ugands via [Co8r(en)2(Ham)] (Ham = Heta or L-Hpra) according to 8uckingham et al. Each complex was separated into two diastereoisomers by Sephadex chromatography. 

Magnetic exchange interactions have also been identified in the oxovanadium-(iv) complexes with the Schiff bases derived from 2-hydroxy-l-naphthaldehyde and ethanolamine or propanolamine. Such complexes can accommodate two further donor atoms per metal and [VO(A)(L)] (A = bipy or phen HjL = Schiff base from salicylaldehyde or 2-hydroxy-l-naphthaldehyde with glycine, alanine, anthranilic acid, or o-aminophenol) complexes have been shown to involve six-co-ordinate vanadium. Similarly, VOL,B [HjL = 2-hydroxy-naphthylideneamino-acid, B = HjO, phen, or (py)2 HjL = 2-hydroxy-naphthylidene-o-aminophenol, B = phen] have normal magnetic moments ifi = 1.70—1.74 BM) at room temperature. The complex VOL (HjL = 6,ll-dimethyl-7,10-diazahexadeca-6,10-diene-2,4,13,15-tetrone) has been prepared from V0(0H)2, heptane-2,4,6-trione, and en in MeOH. The structure... 

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