Ethanol 1-methyl, phosphonate

Hydrogen-bond formation with phenol has been used in an i.r. study of v-(P=0) in the dioxaphospholans (98) to show that basicity depends on the nature of R and increases in the order OMeeight-membered 1,3,6,2-dioxazaphosphocines (99), which are currently of interest for comparison with the better known six-membered analogues, can be obtained from methyl-phosphonic dichloride and the appropriate 2,2 -iminobis(ethanol)." ... 

Phosphorus-based synthons for acetoacetic ester and acetylacetone derivatives are described the phosphonate (78) has been used in the preparation of the /S-ketoester (79), a key intermediate in a synthesis of the fungal sex hormone, trisporic acid B methyl ester (80). Michael addition of an a-methylene ketone to 2,2-diethoxyvinylidenetriphenylphosphorane followed by loss of ethanol gives a valuable reagent (81) for the preparation of 1,3-dioxopent-4-enes by Wittig reaction with aldehydes the intermediate enol ethers (82) can be isolated if desired. 

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