Ethanol metabolism and gluconeogenesis

Answer The first step in the synthesis of glucose from lactate in the liver is oxidation of the lactate to pyruvate like the oxidation of ethanol to acetaldehyde, this requires NAD+. Consumption of alcohol forces a competition for NAD+ between ethanol metabolism and gluconeogenesis, reducing the conversion of lactate to glucose and resulting in hypoglycemia. The problem is compounded by strenuous exercise and lack of food because at these times the level of blood glucose is already low. 

See also LDH Isoenzymes, Pyruvate/Lactate/Ethanol Metabolism, Anaerobic Process for Generating Metabolic Energy, Lactic Acid Fermentation, Ethanol Metabolism and Gluconeogenesis... 

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