Ethanol ADH and

ADH catalyzes the oxidation process in the cytosol of the hepatocyte, forming a complex of ethanol, ADH and NAD". The reaction consists in transferring the hydrogen from the ethanol molecule to NAD" with parallel formation of acetaldehyde. 

Similarly, another study (Ohno et al. 2013) confirmed that deletion of the ethanol (adhE) and acetate (pta) productiOTi pathways is essential for high-titre production of -butanol in engineered E. coli cells. In this study, constraint-based metabolic flux simulation was used to predict the effect of different triple knockouts on the productivity of butanol and identify knockout candidates. Also, the authors proposed leading the flux through the pentose phosphate pathway to increase the pool of NADPH that could make further NADH available for -butanol productirai because of transhydrogenase activity (Ohno et al. 2013). 

---

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

---