Estrone urinary excretion

Conversion of androstenedione to estrone and of testosterone to estradiol by peripheral tissue (fat cells) rather than liver probably explains the increased urinary excretion of estrogen in patients with liver cirrhosis. 

Reifenstein and Dempseyl9 using Talbot s colorimetric method found the urinary "estrone" to vary from 10 to 39 ig. per day in 5 normal women and from 27 to 40 ig. per day for 5 normal men. Attention was not paid to the question of whether the observed differences were primarily inter-individual. In another study20 involving 3 men and 2 women, Pincus found about a 12-fold variation between the two women. One woman excreted over a period of several days estradiol + estrone + estriol to the extent of 155.2 ig. per day for the other woman and the 3 men, the corresponding values were respectively 13.4 ig., 12.4 ig., 7.6 ig. and 16.8 ig. 

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