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Estrogen-responsive elements ERE

Fig. 4.7 The FAAH promoter. Comparison of the upstream transcription factor binding sites of human and mouse FAAH promoters (not drawn to scale). Arrows indicate SP-1 binding sites on the - ( ) or + ( ) strand. An Ikaros (Ik) binding site, a cyclicAMP responsive-like element (CRE), and an estrogen-responsive element (ERE) are schematically represented in boxes... Fig. 4.7 The FAAH promoter. Comparison of the upstream transcription factor binding sites of human and mouse FAAH promoters (not drawn to scale). Arrows indicate SP-1 binding sites on the - ( ) or + ( ) strand. An Ikaros (Ik) binding site, a cyclicAMP responsive-like element (CRE), and an estrogen-responsive element (ERE) are schematically represented in boxes...
Estradiol binds to a nuclear receptor on DNA. This results in destabilization of support protein structure, and exposes the estrogen response element (ERE). The receptor-hormone complex... [Pg.244]

Fig. 8.3 Yeast-based screen for agonists or antagonists of the human estrogen receptor. The hormone estrogen (estradiol) binds to the estrogen receptor which is expressed from a gene driven by the PGK promoter. The hormone-receptor complex binds to an estrogen-responsive element (ERE) that controls the expression of the p-galactosidase reporter gene. The assay measures the activity of the enzyme using a substrate that forms a colored product on conversion. Fig. 8.3 Yeast-based screen for agonists or antagonists of the human estrogen receptor. The hormone estrogen (estradiol) binds to the estrogen receptor which is expressed from a gene driven by the PGK promoter. The hormone-receptor complex binds to an estrogen-responsive element (ERE) that controls the expression of the p-galactosidase reporter gene. The assay measures the activity of the enzyme using a substrate that forms a colored product on conversion.
The hormone receptor proteins are composed of several domains, the central domain being involved in DNA binding (DBD). It is a small, highly conserved domain which contains 65-70 residues, organised as two perpendicular helices and stabilised by two zinc ions. The DNA response elements (RE) consist of two hexameric half sites, arranged as a palindrome or a repeat, separated by a few base pairs. In the case of estrogen response element (ERE), the consensus... [Pg.464]

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See also in sourсe #XX -- [ Pg.181 , Pg.184 , Pg.191 , Pg.373 ]



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EREDs

ErES

Estrogen response element

Estrogen response elements Estrogens

Response elements

Responsive element

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