Establishing temporal CNS intercompartmental relationships in rats

These data afford important pharmacokinetic parameters providing insight into both the rate and extent of compound CNS penetration and the rates of elimination from each neurocompartment. Knowing matrix-specific diffusional and elimination rates is important as compounds may have intercompartmental concentration-related delays and/or much longer half-lives in brain tissue versus CSF or plasma. Such phenomena are critical especially if hysteresis is observed in a Cp-response relationship [43]. Furthermore, a combination of AUC-derived values for each neuromatrix and compound-specific rat /up and f h[l values, determined 

Importantly, these ratios are net values comprised of metabolic, passive, and active components that dictate CNS intercompartmental 

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