Esperal - Disulfiram

A 49-year-old woman developed pruritic erythema 2 weeks after the implantation of a modified-release formulation of disulfiram, Esperal, in her left buttock (28). Three months later she started drinking alcohol and developed generalized erythema with numerous papules on her face and limbs the dermatitis at the site of the implant became more severe. The serum ethanol concentration was 270mg/dl. Methanol was not detected. 

Dupuy O, Flocard F, Vial C, Rode G, Charles N, Boisson D, Flechaire A. Toxicite du disulfirame (Esperal). A propos de trois observations originates. [Disulfiram (Esperal) toxicity. Apropos of 3 original cases.] Rev Med Interne 1995 16(l) 67-72. 

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