Eshweiler-Clarke reaction

We realized that using a low boiling liquid in a microwave environment, even on a small scale, did not constitute best practice and as for hydrogenations our thoughts turned to using formates in a modified Eshweiler-Clarke reaction [65-67] and successfully methylated a number of primary and secondary amines under microwave conditions (Scheme 13.6) [68]. 

Scheme 13.6 Microwave-enhanced methylation using Eshweiler-Clarke reaction.

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