Erythromycin dihydro

In some cases enzymes can increase the rate of reaction by up to lO times. Carnell and Roberts (1997) have briefly discussed the scope of biotransformations that are used to make pharmaceuticals like penicillins, cephalosporines, erythromycin, lovastatin, cyclosporin, etc., and for food additives like citric acid, L-glutamate, and L-lysine. A very successful transformation by Zeneca has been that of benzene reduction, with Pseudomonase Putida, to dihydrocatechol and catechol the dihydro derivative is used to produce (+/-) pinitol. Fluorobenzene has been converted to fluorodihydrocatechol, an intermediate for pharmaceuticals. The highly stereo selective Bayer-Villeger reaction has been carried out with genetically engineered S-cerevisvae. Hydrolases have allowed enantioselective, and in some cases regioselective, hydrolysis of racemic esters. 

Bitterness l-(2,3-Dihydro-5-methoxybenzo[ >]furan- 2-ylmethyl)-4-(o-methoxyphenyl)pipera- zine Erythromycin... 

Djokic, S., Kobrehel, G., and Lazarevski, G. (1987). Erythromycin series. XII. Antibacterial in vitro evaluation of 10-dihydro-10-deoxo-11-azaerythromycin A Synthesis and structure-activity relationship of its acyl derivatives. J. Antibiot. 40, 1006-1015. 

Djokic, S., Kobrehel, G., Lopotar, N., Kamenar, B., Nagl, A., andMrvos, D. (1988). Erythromycin series. Part 13. Synthesis and structure elucidation of lO-dihydro-lO-deoxo-ll-methyl-11-azaerythromycin A. J. Chem. Res. (S), 152-153. 

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