Erythromycin children

It can be seen in the above prescription that age of the child is just two months, and one teaspoonful (containing 200 mg/5 mL) three times daily appears to be high. Therefore the dose has to be lowered. The usual adult dose of erythromycin is 400 mg every six hours. In the present problem, Fried s Equation will be used as follows ... 

Lee DO, Lee CD. Serotonin syndrome in a child associated with erythromycin and sertraline. Pharmacotherapy 1999 19(7) 894-6. 

Standard dosage for tetracycline is 250 mg four times daily for approximately 4 to 6 weeks. Results of the therapy then are assessed, and the medication is tapered over a more extended period. Doxycycline is as effective as tetracycline when used in a dosage of 100 mg twice daily by mouth over a 3- to 6-week period. As with tetracycline, this dose, if effective, may be tapered to as low as 50 mg/day for approximately 1 month and then to 50 mg every other day for several weeks, as long as effectiveness is sustained. When doxycycline is not effective, the recommended therapy is tetracycline, 250 mg four times daily. Erythromycin may be substituted when treating children with dosing based on the child s age and weight. 

Prevention of spread amongst contacts (in epidemics and/or sporadic cases). Spread of influenza A can be partially prevented by amantadine in an outbreak of meningococcal meningitis, or when there is a case in the family, rifampicin may be used very young and fragile nonimmune child contacts of pertussis might benefit from erythromycin... 

Erythromycin An isolated report describes the development of what was thought to be serotonin syndrome in a 12-year-old child taking sertraline when erythromycin was added. 

Two isolated reports describe valproate toxicity in a woman and a child given erythromycin. Another report describes vitamin K deficiency in a child given valproate and erythromycin. 

Fisman S, Diaz P. Erythromycin and clomipramine Noncompetitive inhibition of demethyla-tion. Reply. J Child Adolesc Psychopharmacol (1996) 6, 213. 

A 21-month-old girl was prescribed erythromycin for an upper respiratory tract infection. At the same time, her parents had been giving her approximately 300 mg of aspirin every 4 hours. The child s condition deteriorated and 2 days later she was admitted to hospital with a temperature of 105°F. She was then prescribed more aspirin, and shortly thereafter had a convulsion for which she was given phenobarbitonc, dexamethasone and tetracycline. Fluid therapy was started, but there was no urine output, and she became progressively obtunded and hyperpnoeic. The patient was transferred to another hospital where the diagnosis to salicylate poisoning was made. She appeared well hydrated, the arterial blood pH was 7.26 and the serum salicylate concentration was 470 Mg/ml. Forced alkaline diuresis was started but had to be restricted because of poor urine output, periorbital oedema and hyponatraemia. The plasma osmolality fell to 264 mOsm/1. Diuresis with recovery eventually followed fluid restriction and administration of mannitol (20 -). 

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