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Ergoline dopaminergic activity

Subsequently, similar and independent conclusions by workers at the Eli Lilly laboratories led them to synthesize and test the pyrroleethylamine derivatives IV-VI (9J. These all demonstrated ergoline-like dopaminergic activity, with the... [Pg.204]

The dopaminergic activities of some newer ergolines (1 ) and ergolenes (1 ) have been studied. Compound (CH 29-717) is potent (10 x 15a) in suppression of hyperprolactinemia in rats. ° In behavioral and biochemical models 14c (CM 29-712) is generally bromocriptine-like in its DA agonist effects. pjjg ergolene 15b (CF 25-397) induces... [Pg.19]

Ohno S, Koumori M, Adachi Y, Mizukoshi K, Nagasaka M, Ichihara K. Synthesis and structure-activity relationships of new (5R,8S,10R)-ergoline derivatives with antihypertensive or dopaminergic activity. Chem Pharm Bull 42 2042-2048, 1994. [Pg.425]

Nevertheless, Cannon et al. have prepared several hydroxylated octahydrobenzo[f]quinolines which are very potent dopaminergics (12). These findings have generated considerable controversy regarding which portions of the ergolines are necessary for activity. [Pg.206]

See other pages where Ergoline dopaminergic activity is mentioned: [Pg.201]    [Pg.204]    [Pg.206]    [Pg.215]    [Pg.877]    [Pg.180]    [Pg.725]    [Pg.930]    [Pg.9]    [Pg.207]    [Pg.212]    [Pg.426]    [Pg.430]    [Pg.566]    [Pg.67]    [Pg.387]    [Pg.387]    [Pg.419]    [Pg.426]    [Pg.428]    [Pg.452]    [Pg.460]   
See also in sourсe #XX -- [ Pg.215 ]



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Dopaminergic

Dopaminergics

Ergoline

Ergolines

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