1,2-Epoxypropane bromide

Currently available BAS include cholestyramine, colestipol and colesevelam hydrochloride (colestimide). Cholestyramine comprises a long-chain polymer of styrene with divinylbenzene trimethylbenzylammonium groups, whereas colestipol is a long-chain polymer of l-chloro-2,3-epoxypropane with diethylenetriamine. Colesevelam HCl is poly(allylamine hydrochloride) cross-linked with epichlorohydrin and alkylated with 1-bromodecane and 6-bromo-hexyl-trimethylammonium bromide. Bile-acid binding is enhanced and stabilised in the latter compound by long hydrophobic sidechains, increased density of primary amines, and quaternary amine sidechains. For this reason, colesevelam HCl exhibits increased affinity, specificity and capacity to bind bile acids compared with the other BAS. Colesevelam HCl also binds dihydroxy and trihydroxy bile acids with equal affinity, contrasting with cholestyramine and colestipol that preferentially bind dihydroxy bile acids (CDCA and deoxycholic acid). The latter BAS can lead to an imbalance towards trihydroxy bile acids and a more hydrophilic bile-acid pool. 

El-Amamy and Mill (1984) measured the effect of the surface acidity of mont-morillonite and kaolinite on the hydrolysis rate constants for a number of chemicals containing hydrolyzable functional groups that exhibit acid-catalyzed, base-catalyzed, and neutral hydrolysis. The chemicals that were studied included ethyl acetate, cyclohexene oxide, isopropyl bromide, l-(4-methoxyphenyl)-2,3-epoxypropane, and N-methyl-p-tolyl carbamate (MTC). Aqueous suspensions of... 

Bromomethyl)oxirane optical isomer> syn. GEpibromohydrinGl-Bromo-2,3-epoxypropane Bromopentafluorobenzene 1-Bromopropane syn. GPropyl bromide Buta-1,3-diene... 

Epichlorohydrin. l-Chloro-2,3-epoxypropane, 856, 978, 984 2-Ethylhydroquinone dimethylether. 2-Ethyl-l,4-dimethoxybenzene, 875 4-Ethylpyrogallol. 4-Ethyl-l,2,3-benzenetriol, 834 2-Ethylresorcinol. 2-Ethyl-l,3-benzenediol, 824 4-Ethylresorcinol. 4-Ethyl-l,3-benzenediol, 825 4-Ethylresorcinol diacetate. 4-Elhyl-l,3-benzenediol diacetate, 825 Farnesyl bromide. 3,7,ll-trimethyl-2,6,10-dodecatrienyl bromide, 1081,... 

---