Eplerenone hormonal

ACE inhibitors do not completely block aldosterone synthesis. Since this steroid hormone is a potent inducer of fibrosis in the heart, specific antagonists, such as spironolactone and eplerenone, have recently been very successfully used in clinical trials in addition to ACE inhibitors to treat congestive heart failure [5]. Formerly, these drugs have only been applied as potassium-saving diuretics in oedematous diseases, hypertension, and hypokalemia as well as in primary hyperaldosteronism. Possible side effects of aldosterone antagonists include hyperkalemia and, in case of spironolactone, which is less specific for the mineralocorticoid receptor than eplerenone, also antiandrogenic and progestational actions. 

DlIJRETICS-eplerenone 15. 5-HT1 AGONISTS - almotriptan, eletriptan 16. GESTRINONE 17. OESTROGENS 18. PROGESTOGENS 19. THYROID HORMONES - levothyroxine... 

Eplerenone 100 mg daily was given to 24 healthy subjects on days 1 to 11 of a 28-day cycle of a combined hormonal contraceptive (ethinylestradi-oEnorethisterone 35 micrograms/1 mg). There was no change in the ethinylestradiol AUC, but there was a small 17% increase in the nore-thisterone AUC, which is unlikely to be clinically relevant. ... 

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