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Epitope-masking effect

The exact mechanism by which HIER works is unknown. It is thought to reverse the masking effects of formaldehyde fixation and routine tissue processing. Hydrolytic-proteolytic cleavage of formaldehyde-related crosslinks, unfolding of inner epitopes, as well as the extraction of calcium ions from coordination complexes with proteins are among the hypothesized mechanisms (13-15). [Pg.86]

To accomplish the aforementioned and other antigenicity detection goals, epitopes must be detected reliably and reproducibly in archival, paraffin-embedded tissues. Since fixation is the most important factor in preserving and masking antigenicity in archival and other specimens, a brief comment on the effects of various fixatives on epitopes is relevant. There is no universally ideal fixative to optimally detect all types of epitopes in archival tissues. A few examples suffice. [Pg.173]

See other pages where Epitope-masking effect is mentioned: [Pg.198]    [Pg.198]    [Pg.261]    [Pg.95]    [Pg.120]    [Pg.87]    [Pg.574]    [Pg.105]    [Pg.261]    [Pg.520]    [Pg.317]    [Pg.22]    [Pg.48]    [Pg.53]    [Pg.57]    [Pg.117]    [Pg.120]    [Pg.122]    [Pg.144]    [Pg.173]    [Pg.165]    [Pg.492]    [Pg.376]    [Pg.52]    [Pg.441]    [Pg.19]    [Pg.56]    [Pg.104]    [Pg.50]    [Pg.338]    [Pg.317]    [Pg.133]    [Pg.376]    [Pg.255]    [Pg.181]   
See also in sourсe #XX -- [ Pg.198 ]



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