4-Epishikimic acid synthesis

The syntheses of [5- H] labelled 5-epishikimic acid and [6 H] labelled shikimic acid have been achieved from L-shikimic acid. The synthesis of several deuterated and "C derivatives of shikimic acid has been described in order to study the biosynthesis of ansatrienin (a member of the ansamycin antibiotics). These derivatives were also used in feeding experiments to determine the biosynthesis of the cyclohexanecarboxylic acid starter unit of ca-cyclohexyl fatty acids in Alicyclobacillus acidocaldarius. ... 

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