Epinephryl borate

Chemical Name 4-[1-hvdroxv-2-(methvlamino)ethyl]-1,2-benzenediol borate Common Name Methylaminoethanolcatechol borate adrenalin borate 

Epinephrine may be made by isolation from animal adrenal glands or may be synthesized as described by Payne in Ind. Chemist, 37, 523 (1961). 

It has been found that epinephrine solutions having a physiological pH and which are stable for months in storage can be prepared by combining with the epinephrine a small amount of sodium bisulfite, boric acid, and oxine (8-hydroxy-quinoline) hereinafter called 8-quinoli-nol and adjusting the pH with an alkali, such as sodium hydroxide, to the desired pH. 

It has been found that from 0.001 to 0.1% of 8-quinolinol can be used. From 0.2 to 5% boric acid may be used. The amount of sodium bisulfite can be varied from 0.1 to 1%. 

The solutions can contain from 0.1 to 4% epinephrine. The pHs of the solutions can be adjusted to any value within the physiological range, I.e., from 6.5 to 8.5 using any convenient alkali such as sodium hydroxide. 

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Epinephryl borate Boron trifluoride etherate Nimetazepam Bromine... 

Epinephrine is available as epinephrine hydrochloride and epinephryl borate solutions. The various salts of epinephrine produce equivalent lOP-lowering effects and adverse reactions. Patients with minor ocular irritation from one salt of epinephrine occasionally may benefit from use of another salt because of differences in pH of the commercial solutions. 

Form 3,4-cyclic borate, (, 11 l BNO, epinephryl borate, F.ptnal, Eppy. 

Cyclic borate [5579-16-8]. Epinephryl borate, USAN. Epinal... 

Epinephrine bitartrate, in A-00066 Epinephryl borate, in A-00066 11-Epitaurin, in 0-00063 Epitetracycline hydrochloride, in T-00039... 

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